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Windows: Ctrl + k
or Edit > Preferences > General
Image Interpolation: Set to “Nearest Neighbor”. This will make sure Photoshop keeps crisp pixels when doing any resizing or scaling of your artwork. Nearest Neighbor means when you do any re-sizing and scaling of your work, Photoshop will refer to the pixels around it and create more of those. If you go back and forth between pixel art and other smooth graphic or photo-editing, you should remember to change this back to the default “Bicubic” when finished.
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